1tfc Summary

pdbe.org/1tfc
spacer

CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH A STEROID RECEPTOR COACTIVATOR-1 PEPTIDE

The structure was published by Greschik, H., Flaig, R., Renaud, J.P., and Moras, D., in 2004 in a paper entitled "Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen-related receptor gamma and steroid receptor coactivator-1.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen-related receptor gamma P62508 (229-458) (ERR3_HUMAN)search Homo sapienssearch < 90% 251 90%
B Estrogen-related receptor gamma P62508 (229-458) (ERR3_HUMAN)search Homo sapienssearch < 90% 251 90%
C steroid receptor coactivator-1 Q15788 (686-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 15 73%
D steroid receptor coactivator-1 Q15788 (686-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 15 73%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62508 (229 - 458) Estrogen-related receptor gamma Homo sapiens
Q15788 (686 - 700) steroid receptor coactivator-1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Nuclear receptor coactivator Src-1search Steroid receptor coactivatorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P62508) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search Epsin-like, N-terminalsearch Steroid receptor coactivatorsearch