1tf0 Summary

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Crystal structure of the GA module complexed with human serum albumin

The structure was published by Lejon, S., Frick, I.-M., Bjorck, L., Wikstrom, M., and Svensson, S., in 2004 in a paper entitled "Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Serum albumin and Peptostreptococcal albumin-binding protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serum albumin P02768 (25-596) (ALBU_HUMAN)search Homo sapienssearch 97% 572 97%
B Peptostreptococcal albumin-binding protein Q51911 (213-265) (PAB_FINMA)search Finegoldia magnasearch < 90% 53 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P02768 (25 - 596) Serum albumin Homo sapiens
Q51911 (213 - 265) Peptostreptococcal albumin-binding protein Finegoldia magna ATCC 29328

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P02768) Serum albumin-likesearch Serum Albumin; Chain A, Domain 1search PF00273: Serum albumin familysearch
B GA module, an albumin-binding domainsearch Albumin-binding domainsearch GA modulesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P02768) extracellular regionsearch extracellular spacesearch extracellular vesicular exosomesearch cytoplasmsearch protein complexsearch platelet alpha granule lumensearch basement membranesearch drug bindingsearch fatty acid bindingsearch lipid bindingsearch protein bindingsearch antioxidant activitysearch toxic substance bindingsearch chaperone bindingsearch enzyme bindingsearch DNA bindingsearch metal ion bindingsearch pyridoxal phosphate bindingsearch copper ion bindingsearch zinc ion bindingsearch oxygen bindingsearch transportsearch cellular response to starvationsearch response to mercury ionsearch transmembrane transportsearch lipoprotein metabolic processsearch response to nutrientsearch negative regulation of apoptotic processsearch bile acid and bile salt transportsearch response to organic substancesearch platelet degranulationsearch small molecule metabolic processsearch bile acid metabolic processsearch blood coagulationsearch response to stresssearch platelet activationsearch hemolysis by symbiont of host erythrocytessearch positive regulation of circadian sleep/wake cycle, non-REM sleepsearch maintenance of mitochondrion locationsearch negative regulation of programmed cell deathsearch response to platinum ionsearch sodium-independent organic anion transportsearch
B (Q51911) pathogenesissearch

Chain InterPro annotation
A ALB/AFP/VDBsearch Serum albumin, N-terminalsearch Serum albumin, conserved sitesearch Serum albumin-likesearch Serum albumin/Alpha-fetoproteinsearch
B Protein G-related, albumin-binding GA modulesearch Immunoglobulin/albumin-binding domainsearch