1ta3 Summary


Crystal Structure of xylanase (GH10) in complex with inhibitor (XIP)

The structure was published by Payan, F., Leone, P., Porciero, S., et al., Gilbert, H.J., Juge, N., and Roussel, A., in 2004 in a paper entitled "The Dual Nature of the Wheat Xylanase Protein Inhibitor XIP-I: STRUCTURAL BASIS FOR THE INHIBITION OF FAMILY 10 AND FAMILY 11 XYLANASES." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely xylanase inhibitor protein I and Endo-1,4-beta-xylanase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A xylanase inhibitor protein I Q8L5C6 (31-304) (XIP1_WHEAT)search Triticum aestivumsearch 100% 274 100%
B Endo-1,4-beta-xylanase Q00177 (25-327) (XYNC_EMENI)search Aspergillus nidulans FGSC A4search 100% 303 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8L5C6 (31 - 304) xylanase inhibitor protein I Triticum aestivum
Q00177 (25 - 327) Endo-1,4-beta-xylanase Aspergillus nidulans

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q8L5C6) Type II chitinasesearch Glycosidasessearch PF00704: Glycosyl hydrolases family 18search
B (Q00177) beta-glycanasessearch Glycosidasessearch PF00331: Glycosyl hydrolase family 10search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q8L5C6) hydrolase activity, hydrolyzing O-glycosyl compoundssearch carbohydrate metabolic processsearch defense responsesearch extracellular regionsearch
B (Q00177) hydrolase activitysearch hydrolase activity, acting on glycosyl bondssearch hydrolase activity, hydrolyzing O-glycosyl compoundssearch endo-1,4-beta-xylanase activitysearch carbohydrate metabolic processsearch xylan catabolic processsearch metabolic processsearch D-xylose metabolic processsearch polysaccharide catabolic processsearch extracellular regionsearch

Chain InterPro annotation
A Glycoside hydrolase, family 18, catalytic domainsearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase superfamilysearch
B Glycoside hydrolase, family 10search Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase superfamilysearch