› 1t7h

X-ray diffraction
1.13Å resolution

X-ray structure of [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide

Released:
DOI: 10.2210/pdb1t7h/pdb
PDB entry 1t7h coloured by chain, front view.
PDB entry 1t7h coloured by chain, side view.
PDB entry 1t7h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution X-ray structure of the unexpectedly stable dimer of the [Lys(-2)-Arg(-1)-des(17-21)]endothelin-1 peptide.
Hoh F, Cerdan R, Kaas Q, Nishi Y, Chiche L, Kubo S, Chino N, Kobayashi Y, Dumas C, Aumelas A
Biochemistry 43 15154-68 (2004)
PMID: 15568807

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endothelin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 18 amino acids
Theoretical weight: 2.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05305 (Residues: 51-68; Coverage: 9%)
Gene name: EDN1
Sequence domains: Endothelin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 30.136Å b: 53.926Å c: 19.486Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.122 0.12 0.134
Expression system: Not provided

Quick links

Citations

1 review citation

The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors.
Vu et al. (2021)
3 other articles

8 mentions without citation

Endothelin-1 gene regulation.
Stow et al. (2011)
7 more