1t7d Summary

pdbe.org/1t7d
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Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor

The structure was published by Paetzel, M., Goodall, J.J., Kania, M., Dalbey, R.E., and Page, M.G.P., in 2004 in a paper entitled "Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.47 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SIGNAL PEPTIDASE I and ARYLOMYCIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SIGNAL PEPTIDASE I P00803 (76-324) (LEP_ECOLI)search Escherichia coli K-12search < 90% 250 89%
B SIGNAL PEPTIDASE I P00803 (76-324) (LEP_ECOLI)search Escherichia coli K-12search < 90% 250 89%
C ARYLOMYCIN A2 Not available
Streptomyces sp.search Not available 6 100%
D ARYLOMYCIN A2 Not available
Streptomyces sp.search Not available 6 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00803 (76 - 324) SIGNAL PEPTIDASE I Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Type 1 signal peptidasesearch Umud Fragment, subunit Asearch, Signal Peptidase I; Chain: A, domain 2search Peptidase S24-likesearch, Signal peptidase, peptidase S26search
C, D

Chain Molecule NORINE reference
C, DARYLOMYCIN A2NOR01115, NOR01115

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P00803) integral component of membranesearch membranesearch serine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A, B Peptidase S26A, signal peptidase Isearch Peptidase S24/S26A/S26B/S26Csearch Peptidase S26search Peptidase S26A, signal peptidase I, serine active sitesearch Peptidase S26A, signal peptidase I, lysine active sitesearch Peptidase S26A, signal peptidase I, conserved sitesearch Peptidase S24/S26A/S26Bsearch Peptidase S26A, all-beta subdomainsearch Peptidase S24/S26, beta-ribbon domainsearch
C, D