1t79 Summary


Crystal structure of the androgen receptor ligand binding domain in complex with a FxxLW motif

The structure was published by Hur, E., Pfaff, S.J., Payne, E.S., Gron, H., Buehrer, B.M., and Fletterick, R.J., in 2004 in a paper entitled "Recognition and accommodation at the androgen receptor coactivator binding interface." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Androgen receptor and FxxLW motif peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Androgen receptor O97775 (654-911) (ANDR_PANTR)search Pan troglodytessearch < 90% 269 92%
B FxxLW motif peptide Not available
Synthetic Not available 20 40%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O97775 (654 - 911) Androgen receptor Pan troglodytes

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (O97775) nucleussearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch