› 1t6n

X-ray diffraction
1.94Å resolution

Crystal structure of the N-terminal domain of human UAP56

Released:
DOI: 10.2210/pdb1t6n/pdb
PDB entry 1t6n coloured by chain, front view.
PDB entry 1t6n coloured by chain, side view.
PDB entry 1t6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export.
Zhao R, Shen J, Green MR, MacMorris M, Blumenthal T
Structure 12 1373-81 (2004)
PMID: 15296731

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171825 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spliceosome RNA helicase DDX39B Chains: A, B
Molecule details ›
Chains: A, B
Length: 220 amino acids
Theoretical weight: 25.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13838 (Residues: 34-251; Coverage: 51%)
Gene names: BAT1, DDX39B, UAP56
Sequence domains: DEAD/DEAH box helicase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand FLC 2 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID, APS BEAMLINE 19-BM, APS BEAMLINE 14-BM-C
Spacegroup: P21
Unit cell:
a: 49.453Å b: 47.284Å c: 87.19Å
α: 90° β: 98.23° γ: 90°
R-values:
R R work R free
0.216 0.216 0.255
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The DEAD-box protein family of RNA helicases.
Cordin et al. (2006)
8 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)