1t63 Summary


Crystal Structure of the Androgen Receptor Ligand Binding Domain with DHT and a peptide derived from its physiological coactivator GRIP1 NR box3

The structure was published by Estebanez-Perpina, E., Moore, J.M.R., Mar, E., et al., Webb, P., Fletterick, R.J., and Guy, R.K., in 2005 in a paper entitled "The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.07 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Androgen receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Androgen receptor P10275 (669-918) (ANDR_HUMAN)search Homo sapienssearch < 90% 251 99%
B Nuclear receptor coactivator 2 Q15596 (740-753) (NCOA2_HUMAN)search Homo sapienssearch < 90% 14 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P10275 (669 - 918) Androgen receptor Homo sapiens
Q15596 (740 - 753) Nuclear receptor coactivator 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P10275) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch