STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
The structure was published by Mol, C.D., Dougan, D.R., Schneider, T.R., et al., Zou, H., Sang, B.C., and Wilson, K.P., in 2004 in a paper entitled "Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2004.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. This molecule has the UniProt identifier P10721 (KIT_HUMAN). The sample contained 313 residues which is < 90% of the natural sequence. Out of 313 residues 297 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: