1t45 Summary

pdbe.org/1t45
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STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE

The structure was published by Mol, C.D., Dougan, D.R., Schneider, T.R., et al., Zou, H., Sang, B.C., and Wilson, K.P., in 2004 in a paper entitled "Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. This molecule has the UniProt identifier P10721 (KIT_HUMAN)search. The sample contained 331 residues which is < 90% of the natural sequence. Out of 331 residues 330 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog P10721 (547-693) (KIT_HUMAN)search Homo sapienssearch < 90% 331 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10721 (547 - 693) Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P10721) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transmembrane receptor protein tyrosine kinase activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch