1t3l Summary

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Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core in Complex with Alpha1 Interaction Domain

The structure was published by Opatowsky, Y., Chen, C.-C., Campbell, K.P., and Hirsch, J.A., in 2004 in a paper entitled "Structural Analysis of Voltage-Dependent Calcium Channel Beta Subunit Functional Core and Its Complex with the Alpha1 Interaction Domain" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Dihydropyridine-sensitive L-type, calcium channel beta-2 subunit and Voltage-dependent L-type calcium channel alpha-1S subunit.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dihydropyridine-sensitive L-type, calcium channel beta-2 subunit P54288 (51-163) (CACB2_RABIT)search ,
P54288 (229-448) (CACB2_RABIT)search
Oryctolagus cuniculussearch ,
Oryctolagus cuniculussearch
< 90% ,
< 90%
337 90%
B Voltage-dependent L-type calcium channel alpha-1S subunit P07293 (357-374) (CAC1S_RABIT)search Oryctolagus cuniculussearch < 90% 18 94%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P54288 (51 - 163) Dihydropyridine-sensitive L-type, calcium channel beta-2 subunit Oryctolagus cuniculus
P07293 (357 - 374) Voltage-dependent L-type calcium channel alpha-1S subunit

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch, Nucleotide and nucleoside kinasessearch SH3 Domainssearch, P-loop containing nucleotide triphosphate hydrolasessearch Voltage gated calcium channel subunit beta domain 4Aa N terminalsearch, Guanylate kinasesearch
B Fragments of the L-type calcium channel alpha subunit Cav.1 (dihydropyridine receptor)search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P54288) voltage-gated calcium channel complexsearch voltage-gated calcium channel activitysearch calcium ion transmembrane transportsearch

Chain InterPro annotation
A Voltage-dependent calcium channel, L-type, beta subunitsearch Src homology-3 domainsearch Voltage-dependent calcium channel, L-type, beta-2 subunitsearch Guanylate kinase-likesearch Guanylate kinase/L-type calcium channel beta subunitsearch P-loop containing nucleoside triphosphate hydrolasesearch
B