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EBI PDBe PDBeView

PDBe Entry: 1t2f view

Human B lactate dehydrogenase complexed with NAD+ and 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.0 Å, R-factor: 22.06%, Free R-factor: 32.053%, Spacegroup: P 21 21 2
Released 11/05/2004, deposition: 21/04/2004, last revision: 24/02/2009
Authors Cameron, A.search; Read, J.search; Tranter, R.search; Winter, V.J.search; Sessions, R.B.search; Brady, R.L.search; Vivas, L.search; Easton, A.search; Kendrick, H.search; Croft, S.L.search; Barros, D.search; Lavandera, J.L.search; Martin, J.J.search; Risco, F.search; Garcia-Ochoa, S.search; Gamo, F.J.search; Sanz, L.search; Leon, L.search; Ruiz, J.R.search; Gabarro, R.search; Mallo, A.search; De Las Heras, F.G.search
Primary citation Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.
J.BIOL.CHEM.search vol:279, pag:31429-31439 (2004) [PubMed ID 15117937 ]search
Keywords Protein-ligand complexsearch, OXIDOREDUCTASEsearch
EC 1.1.1.27 ExPASy BRENDA search (A B C D)
Organism Homo sapiens(human) 9606search(A B C D)
UniProt L-lactate dehydrogenase B chain (EC 1.1.1.27) (LDH-B) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) P07195search (A B C D)
Solvent A, B, C, D
Related entries 1ldg, 1t24, 1t25, 1t26, 1t2c, 1t2d, 1t2e
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D L-lactate dehydrogenase B chain Protein P07195 (LDHB_HUMAN)search
 333 99%
Heterogens
Id Name Ligands
A, B, C, D NICOTINAMIDE-ADENINE-DINUCLEOTIDE NAD search
A, B, C, D 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID OXQ search
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