1t1q Summary

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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES

The structure was published by Huang, K., Xu, B., Hu, S.Q., et al., De Meyts, P., Katsoyannis, P.G., and Weiss, M.A., in 2004 in a paper entitled "How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely insulin and Insulin.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A insulin P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
B Insulin P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (90 - 110) insulin

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
B (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
Chain InterPro annotation
A Insulin-likesearch Insulin, conserved sitesearch
B Insulin-likesearch