› 1t0z

X-ray diffraction
2.6Å resolution

Structure of an Excitatory Insect-specific Toxin with an Analgesic Effect on Mammalian from Scorpion Buthus martensii Karsch

Released:
DOI: 10.2210/pdb1t0z/pdb
PDB entry 1t0z coloured by chain, front view.
PDB entry 1t0z coloured by chain, side view.
PDB entry 1t0z coloured by chain, top view.
Source organism: Mesobuthus martensii
Primary publication:
Structure of an excitatory insect-specific toxin with an analgesic effect on mammals from the scorpion Buthus martensii Karsch.
Li C, Guan RJ, Xiang Y, Zhang Y, Wang DC
Acta Crystallogr D Biol Crystallogr 61 14-21 (2005)
PMID: 15608371

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-insect excitatory toxin BmK IT-AP Chains: A, B
Molecule details ›
Chains: A, B
Length: 72 amino acids
Theoretical weight: 8.17 KDa
Source organism: Mesobuthus martensii
UniProt:
  • Canonical: O77091 (Residues: 19-90; Coverage: 100%)
Sequence domains: Scorpion toxin-like domain
Structure domains: Knottin, scorpion toxin-like

Ligands and Environments

1 bound ligand:
Ligand SO4 11 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-18B
Spacegroup: P6422
Unit cell:
a: 64.971Å b: 64.971Å c: 173.482Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.2 0.249

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Citations

5 citation in other articles

Mad, bad and dangerous to know: the biochemistry, ecology and evolution of slow loris venom.
Nekaris et al. (2013)
4 more