1t0j Summary

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Crystal structure of a complex between voltage-gated calcium channel beta2a subunit and a peptide of the alpha1c subunit

The structure was published by Van Petegem, F., Clark, K.A., Chatelain, F.C., and Minor, D.L., in 2004 in a paper entitled "Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely voltage-gated calcium channel subunit beta2a and Voltage-dependent L-type calcium channel alpha-1C subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A voltage-gated calcium channel subunit beta2a Q8VGC3 (68-196) (CACB2_RAT)search Rattus norvegicussearch < 90% 132 72%
B voltage-gated calcium channel subunit beta2a Q8VGC3 (254-476) (CACB2_RAT)search Rattus norvegicussearch < 90% 224 83%
C Voltage-dependent L-type calcium channel alpha-1C subunit Q13936 (428-445) (CAC1C_HUMAN)search Homo sapienssearch < 90% 20 80%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8VGC3 (68 - 196) voltage-gated calcium channel subunit beta2a Rattus norvegicus
Q13936 (428 - 445) Voltage-dependent L-type calcium channel alpha-1C subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch Voltage gated calcium channel subunit beta domain 4Aa N terminalsearch
B Nucleotide and nucleoside kinasessearch P-loop containing nucleotide triphosphate hydrolasessearch Guanylate kinasesearch
C Fragments of the L-type calcium channel alpha subunit Cav.1 (dihydropyridine receptor)search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q8VGC3) calcium ion transmembrane transportsearch voltage-gated calcium channel complexsearch voltage-gated calcium channel activitysearch
B (Q8VGC3) calcium ion transmembrane transportsearch voltage-gated calcium channel complexsearch voltage-gated calcium channel activitysearch

Chain InterPro annotation
A Voltage-dependent calcium channel, L-type, beta subunitsearch SH3 domainsearch Voltage-dependent calcium channel, L-type, beta-2 subunitsearch
B Voltage-dependent calcium channel, L-type, beta subunitsearch Guanylate kinase/L-type calcium channel beta subunitsearch P-loop containing nucleoside triphosphate hydrolasesearch
C