1szd Summary details

pdbe.org/1szd/summary_details
spacer Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases
Summary
Header GENE REGULATIONsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.5 Å, R-factor: 22.5%, Free R-factor: 23.0%, Spacegroup: P 32 2 1
Released 15/06/2004, deposition: 05/04/2004, last revision: 13/07/2011
Authors Zhao, K.search; Harshaw, R.search; Chai, X.search; Marmorstein, R.search
Primary citation Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.
PROC.NATL.ACAD.SCI.USAsearch vol:101, pag:8563-8568 (2004) [PubMed 15150415 ]search
Keywords hst2search, Sir2search, Sirtuinsearch, histone deacetylasesearch, protein deacetylasesearch, GENE REGULATIONsearch
EC 3.5.1.- ExPASy BRENDA search (A)
Organism Saccharomyces cerevisiae(baker's yeast) 4932search(A)
UniProt P53686search (A)
P02309search (B)
Solvent A, B
Related entries 1szc, 1q14, 1q1a, 1q17
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A NAD-dependent deacetylase HST2 Protein P53686 (HST2_YEAST)search
297 97%
B Histone H4 peptide Protein P02309 (H4_YEAST)search
10 80%
Heterogens
Chain Id Name Ligands
A CHLORIDE ION CL search
A ZINC ION ZN search
A ADENOSINE-5-DIPHOSPHORIBOSE APR search
A GLYCEROL GOL search
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