1su4 Summary


PDB entry 1su4 (supersedes 1eul)

Crystal structure of calcium ATPase with two bound calcium ions

The structure was published by Toyoshima, C., Nakasako, M., Nomura, H., and Ogawa, H., in 2000 in a paper entitled "Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. This molecule has the UniProt identifier P04191 (AT2A1_RABIT)search. The sample contained 994 residues which is 99% of the natural sequence. Out of 994 residues 994 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 (1-994) (AT2A1_RABIT)search Oryctolagus cuniculussearch 99% 994 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04191 (1 - 994) Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Oryctolagus cuniculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P04191) Calcium ATPase, transduction domain Asearch, Meta-cation ATPase, catalytic domain Psearch, Metal cation-transporting ATPase, ATP-binding domain Nsearch, Calcium ATPase, transmembrane domain Msearch Calcium-transporting ATPase, cytoplasmic transduction domain Asearch, Calcium-transporting ATPase, transmembrane domainsearch, Calcium-transporting ATPase, cytoplasmic domain Nsearch, Rossmann foldsearch PF00122: E1-E2 ATPasesearch, PF00689: Cation transporting ATPase, C-terminussearch, PF00690: Cation transporter/ATPase, N-terminussearch, PF00702: haloacid dehalogenase-like hydrolasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P04191) nucleotide bindingsearch cation-transporting ATPase activitysearch metal ion bindingsearch calcium ion bindingsearch calcium-transporting ATPase activitysearch hydrolase activitysearch ATP bindingsearch calcium ion transportsearch cation transportsearch transportsearch positive regulation of fast-twitch skeletal muscle fiber contractionsearch metabolic processsearch calcium ion transmembrane transportsearch ion transportsearch endoplasmic reticulumsearch integral component of membranesearch sarcoplasmic reticulumsearch endoplasmic reticulum membranesearch sarcoplasmic reticulum membranesearch membranesearch

Chain InterPro annotation
A Cation-transporting P-type ATPasesearch Cation-transporting P-type ATPase, N-terminalsearch Calcium-transporting P-type ATPase, subfamily IIA, SERCA-typesearch Cation-transporting P-type ATPase, C-terminalsearch P-type ATPase, A domainsearch P-type ATPase, phosphorylation sitesearch HAD-like domainsearch P-type ATPase, transmembrane domainsearch P-type ATPase, cytoplasmic domain Nsearch