› 1sr7

X-ray diffraction
1.46Å resolution

Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate

Released:
DOI: 10.2210/pdb1sr7/pdb
PDB entry 1sr7 coloured by chain, front view.
PDB entry 1sr7 coloured by chain, side view.
PDB entry 1sr7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.
Madauss KP, Deng SJ, Austin RJ, Lambert MH, McLay I, Pritchard J, Short SA, Stewart EL, Uings IJ, Williams SP
J Med Chem 47 3381-7 (2004)
PMID: 15189034

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139041 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Progesterone receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06401 (Residues: 676-933; Coverage: 28%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand MOF 2 x MOF
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 58.112Å b: 64.256Å c: 70.091Å
α: 90° β: 96.88° γ: 90°
R-values:
R R work R free
0.176 0.174 0.211
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Nuclear receptor structure: implications for function.
Bain et al. (2007)
4 more

15 mentions without citation

Benchmarking sets for molecular docking.
Huang et al. (2006)
14 more