1spy Summary

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REGULATORY DOMAIN OF HUMAN CARDIAC TROPONIN C IN THE CALCIUM-FREE STATE, NMR, 40 STRUCTURES

The structure was published by Spyracopoulos, L., Li, M.X., Sia, S.K., et al., Chandra, M., Solaro, R.J., and Sykes, B.D., in 1997 in a paper entitled "Calcium-induced structural transition in the regulatory domain of human cardiac troponin C." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TROPONIN C. This molecule has the UniProt identifier P63316 (TNNC1_HUMAN)search. The sample contained 89 residues which is < 90% of the natural sequence. Out of 89 residues 89 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TROPONIN C P63316 (1-89) (TNNC1_HUMAN)search Homo sapienssearch 100% 89 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P63316 (1 - 89) TROPONIN C Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P63316) Calmodulin-likesearch EF-handsearch PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO)
A (P63316) calcium ion bindingsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch