1sps Summary

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BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS

The structure was published by Waksman, G., Shoelson, S.E., Pant, N., Cowburn, D., and Kuriyan, J., in 1993 in a paper entitled "Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SRC SH2 DOMAIN and PEPTIDE YEEI.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SRC SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 99%
B SRC SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 99%
C SRC SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 99%
D PEPTIDE YEEI P03079 (321-331) (MT_POVHA)search Hamster polyomavirussearch < 90% 11 90%
E PEPTIDE YEEI P03079 (321-331) (MT_POVHA)search Hamster polyomavirussearch < 90% 11 90%
F PEPTIDE YEEI P03079 (321-331) (MT_POVHA)search Hamster polyomavirussearch < 90% 11 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00524 (144 - 247) SRC SH2 DOMAIN Rous sarcoma virus
P03079 (321 - 331) PEPTIDE YEEI Hamster polyomavirus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
D, E, F
Chain InterPro annotation
A, B, C SH2 domainsearch
D, E, F