1spr Summary

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BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS

The structure was published by Waksman, G., Shoelson, S.E., Pant, N., Cowburn, D., and Kuriyan, J., in 1993 in a paper entitled "Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of SRC TYROSINE KINASE SH2 DOMAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SRC TYROSINE KINASE SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 100%
B SRC TYROSINE KINASE SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 100%
C SRC TYROSINE KINASE SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 100%
D SRC TYROSINE KINASE SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00524 (144 - 247) SRC TYROSINE KINASE SH2 DOMAIN Rous sarcoma virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A, B, C, D SH2 domainsearch