1sp4 Summary

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Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft

The structure was published by Stern, I., Schaschke, N., Moroder, L., and Turk, D., in 2004 in a paper entitled "Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cathepsin B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin B P07688 (80-127) (CATB_BOVIN)search Bos taurussearch < 90% 48 100%
B Cathepsin B P07688 (128-332) (CATB_BOVIN)search Bos taurussearch < 90% 205 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07688 (80 - 127) Cathepsin B Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Papain-likesearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Papain family cysteine proteasesearch
B Papain-likesearch Cysteine proteinasessearch Papain family cysteine proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P07688) cysteine-type peptidase activitysearch proteolysissearch
B (P07688) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch
B Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch