› 1sor

Electron crystallography
3Å resolution

Aquaporin-0 membrane junctions reveal the structure of a closed water pore

Released:
DOI: 10.2210/pdb1sor/pdb
PDB entry 1sor coloured by chain, front view.
PDB entry 1sor coloured by chain, side view.
PDB entry 1sor coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
Aquaporin-0 membrane junctions reveal the structure of a closed water pore.
Gonen T, Sliz P, Kistler J, Cheng Y, Walz T
Nature 429 193-7 (2004)
PMID: 15141214

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179806 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lens fiber major intrinsic protein Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 25.17 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: Q6J8I9 (Residues: 5-239; Coverage: 89%)
Gene names: AQP0, MIP
Sequence domains: Major intrinsic protein
Structure domains: Glycerol uptake facilitator protein.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å

Quick links

Citations

67 review citations

From structure to disease: the evolving tale of aquaporin biology.
King et al. (2004)
66 more

3 mentions without citation

Aquaporins: important but elusive drug targets.
Verkman et al. (2014)
2 more