1snx Summary

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CRYSTAL STRUCTURE OF APO INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN

The structure was published by Brown, K., Long, J.M., Vial, S.C., et al., Frantz, J.D., Fleming, M.A., and Cheetham, G.M., in 2004 in a paper entitled "Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Tyrosine-protein kinase ITK/TSK.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase ITK/TSK Q08881 (357-620) (ITK_HUMAN)search Homo sapienssearch < 90% 264 92%
B Tyrosine-protein kinase ITK/TSK Q08881 (357-620) (ITK_HUMAN)search Homo sapienssearch < 90% 264 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q08881 (357 - 620) Tyrosine-protein kinase ITK/TSK Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q08881) protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch