1snt Summary

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Structure of the human cytosolic sialidase Neu2

The structure was published by Chavas, L.M.G., Tringali, C., Fusi, P., et al., Kato, R., Monti, E., and Wakatsuki, S., in 2005 in a paper entitled "Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Sialidase 2. This molecule has the UniProt identifier Q9Y3R4 (NEUR2_HUMAN)search. The sample contained 382 residues which is 100% of the natural sequence. Out of 382 residues 352 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sialidase 2 Q9Y3R4 (1-380) (NEUR2_HUMAN)search Homo sapienssearch 100% 382 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y3R4 (1 - 380) Sialidase 2 Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (Q9Y3R4) Sialidases (neuraminidases)search PF13088: BNR repeat-like domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q9Y3R4) exo-alpha-sialidase activitysearch exo-alpha-(2->6)-sialidase activitysearch hydrolase activity, acting on glycosyl bondssearch hydrolase activitysearch exo-alpha-(2->3)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch ganglioside catabolic processsearch lipid metabolic processsearch small molecule metabolic processsearch metabolic processsearch sphingolipid metabolic processsearch carbohydrate metabolic processsearch glycosphingolipid metabolic processsearch oligosaccharide catabolic processsearch lipid catabolic processsearch cytoplasmsearch cytosolsearch

Chain InterPro annotation
A Sialidasessearch Sialidase familysearch Sialidase-2search