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Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain

X-ray diffraction
2.3Å resolution
PDB entry 1sm2 coloured by chain, front view.
PDB entry 1sm2 coloured by chain, side view.
PDB entry 1sm2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase ITK/TSK
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Multimeric state: monomeric
Accessible surface area: 12131.81 Å2
Buried surface area: 862.3 Å2
Dissociation area: 431.15 Å2
Dissociation energy (ΔGdiss): -2.34 kcal/mol
Dissociation entropy (TΔSdiss): 4.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170703
Assembly 2
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Assembly Name: Tyrosine-protein kinase ITK/TSK
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Multimeric state: monomeric
Accessible surface area: 12213.21 Å2
Buried surface area: 872.48 Å2
Dissociation area: 436.24 Å2
Dissociation energy (ΔGdiss): -2.79 kcal/mol
Dissociation entropy (TΔSdiss): 4.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170703

Macromolecules

Tyrosine-protein kinase ITK/TSK
Chains: A, B
Length: 264 amino acids
Theoretical weight: 30.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08881 (Residues: 357-620; Coverage: 43%)
Gene names: EMT, ITK, LYK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Tyrosine-protein kinase ITK/TSK in PDB entry 1sm2, assembly 1, front view.
Tyrosine-protein kinase ITK/TSK in PDB entry 1sm2, assembly 1, side view.
Tyrosine-protein kinase ITK/TSK in PDB entry 1sm2, assembly 1, top view.
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