Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D
The structure was published by Kim, S., Wu, J.Y., Birzin, E.T., et al., Rohrer, S.P., Schaeffer, J.M., and Hammond, M.L., in 2004 in a paper entitled "Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2004.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Estrogen receptor. This molecule has the UniProt identifier P03372 (ESR1_HUMAN). The sample contained 248 residues which is < 90% of the natural sequence. Out of 248 residues 242 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: