› 1sij

X-ray diffraction
2.3Å resolution

Crystal structure of the Aldehyde Dehydrogenase (a.k.a. AOR or MOP) of Desulfovibrio gigas covalently bound to [AsO3]-

Released:
DOI: 10.2210/pdb1sij/pdb
PDB entry 1sij coloured by chain, front view.
PDB entry 1sij coloured by chain, side view.
PDB entry 1sij coloured by chain, top view.
Source organism: Megalodesulfovibrio gigas
Primary publication:
X-ray crystal structure and EPR spectra of "arsenite-inhibited" Desulfovibriogigas aldehyde dehydrogenase: a member of the xanthine oxidase family.
Boer DR, Thapper A, Brondino CD, Romão MJ, Moura JJ
J Am Chem Soc 126 8614-5 (2004)
PMID: 15250689

Function and Biology Details

Reaction catalysed: 
An aldehyde + H(2)O + acceptor = a carboxylate + reduced acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

5 bound ligands:
Ligand CL 3 x CL
Ligand MG 2 x MG
Ligand PCD 1 x PCD
Ligand AST 1 x AST
Ligand FES 2 x FES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6122
Unit cell:
a: 142.78Å b: 142.78Å c: 161.577Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.181 0.223

Quick links

Citations

7 review citations

Arsenic-induced oxidative stress and its reversibility.
Flora et al. (2011)
6 more

3 mentions without citation

The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerization.
Bal et al. (2010)
2 more