1si4 Summary

pdbe.org/1si4
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Crystal structure of Human hemoglobin A2 (in R2 state) at 2.2 A resolution

The structure was published by Sen, U., Dasgupta, J., Choudhury, D., et al., Chakrabarty, S.B., Chakrabarty, A., and Dattagupta, J.K., in 2004 in a paper entitled "Crystal structures of HbA2 and HbE and modeling of hemoglobin delta4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin delta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin delta chain P02042 (2-147) (HBD_HUMAN)search Homo sapienssearch 99% 146 100%
D Hemoglobin delta chain P02042 (2-147) (HBD_HUMAN)search Homo sapienssearch 99% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P02042 (2 - 147) Hemoglobin delta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P02042) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch protein heterooligomerizationsearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch metal ion bindingsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch hemoglobin complexsearch cytosolsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch
B, D (P02042) transportsearch oxygen transportsearch blood coagulationsearch iron ion bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch metal ion bindingsearch cytosolsearch hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch