1si4 Summary

pdbe.org/1si4
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Crystal structure of Human hemoglobin A2 (in R2 state) at 2.2 A resolution

The structure was published by Sen, U., Dasgupta, J., Choudhury, D., et al., Chakrabarty, S.B., Chakrabarty, A., and Dattagupta, J.K., in 2004 in a paper entitled "Crystal structures of HbA2 and HbE and modeling of hemoglobin delta4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin delta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin delta chain P02042 (2-147) (HBD_HUMAN)search Homo sapienssearch 99% 146 100%
D Hemoglobin delta chain P02042 (2-147) (HBD_HUMAN)search Homo sapienssearch 99% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P02042 (2 - 147) Hemoglobin delta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P02042) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen transportsearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch cytosolsearch membranesearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P02042) heme bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch oxygen transporter activitysearch oxygen transportsearch blood coagulationsearch transportsearch hemoglobin complexsearch blood microparticlesearch cytosolsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch