1shb Summary

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CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES

The structure was published by Waksman, G., Kominos, D., Robertson, S.C., et al., Rios, C.B., Silverman, L., and Kuriyan, J., in 1992 in a paper entitled "Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely V-SRC SH2 DOMAIN and PHOSPHOPEPTIDE B.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A V-SRC SH2 DOMAIN P00524 (144-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 104 99%
B PHOSPHOPEPTIDE B Not available
Rous sarcoma virussearch Not available 5 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00524 (144 - 247) V-SRC SH2 DOMAIN Rous sarcoma virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
B
Chain InterPro annotation
A SH2 domainsearch
B