1sg1 Summary

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Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75

The structure was published by He, X.L. and Garcia, K.C., in 2004 in a paper entitled "Structure of nerve growth factor complexed with the shared neurotrophin receptor p75" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Beta-nerve growth factor and Tumor necrosis factor receptor superfamily member 16.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Beta-nerve growth factor P01138 (122-241) (NGF_HUMAN)search Homo sapienssearch < 90% 120 85%
B Beta-nerve growth factor P01138 (122-241) (NGF_HUMAN)search Homo sapienssearch < 90% 120 85%
X Tumor necrosis factor receptor superfamily member 16 P07174 (30-190) (TNR16_RAT)search Rattus norvegicussearch < 90% 161 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01138 (122 - 241) Beta-nerve growth factor Homo sapiens
P07174 (30 - 190) Tumor necrosis factor receptor superfamily member 16 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Neurotrophinsearch Cystine-knot cytokinessearch Nerve growth factor familysearch
X TNF receptor-likesearch Tumor Necrosis Factor Receptor, subunit A, domain 2search TNFR/NGFR cysteine-rich regionsearch

Chain ID Molecular function (GO)
A, B (P01138) receptor bindingsearch

Chain InterPro annotation
A, B Nerve growth factor-relatedsearch Nerve growth factor conserved sitesearch Nerve growth factor-likesearch Nerve growth factor, beta subunitsearch Cystine-knot cytokinesearch
X TNFR/NGFR cysteine-rich regionsearch Tumour necrosis factor receptor 16search