1seb Summary

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COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB

The structure was published by Jardetzky, T.S., Brown, J.H., Gorga, J.C., et al., Stauffacher, C., Strominger, J.L., and Wiley, D.C., in 1994 in a paper entitled "Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This entry contains 8 copies of 4 unique biopolymers (complete list).

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN P01903 (26-206) (DRA_HUMAN)search Homo sapienssearch < 90% 181 100%
E HLA CLASS II HISTOCOMPATIBILITY ANTIGEN P01903 (26-206) (DRA_HUMAN)search Homo sapienssearch < 90% 181 100%
B HLA CLASS II HISTOCOMPATIBILITY ANTIGEN P04229 (30-221) (2B11_HUMAN)search Homo sapienssearch < 90% 192 100%
F HLA CLASS II HISTOCOMPATIBILITY ANTIGEN P04229 (30-221) (2B11_HUMAN)search Homo sapienssearch < 90% 192 100%
C ENDOGENOUS PEPTIDE MODEL, POLY-ALA Not available
Homo sapienssearch Not available 13 100%
G ENDOGENOUS PEPTIDE MODEL, POLY-ALA Not available
Homo sapienssearch Not available 13 100%
D ENTEROTOXIN TYPE B P01552 (29-262) (ETXB_STAAU)search Staphylococcus aureussearch 98% 234 88%
H ENTEROTOXIN TYPE B P01552 (29-262) (ETXB_STAAU)search Staphylococcus aureussearch 98% 234 88%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 206) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN Homo sapiens
P04229 (30 - 221) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN Homo sapiens
P01552 (29 - 262) ENTEROTOXIN TYPE B Staphylococcus aureus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, E C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B, F C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C, G
D, H (P01552) Superantigen toxins, N-terminal domainsearch, Superantigen toxins, C-terminal domainsearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search, Ubiquitin-like (UB roll)search PF01123: Staphylococcal/Streptococcal toxin, OB-fold domainsearch, PF02876: Staphylococcal/Streptococcal toxin, beta-grasp domainsearch

Chain ID Cellular component (GO) Biological process (GO)
A, E (P01903) MHC class II protein complexsearch membranesearch antigen processing and presentationsearch immune responsesearch
B, F (P04229) membranesearch MHC class II protein complexsearch immune responsesearch antigen processing and presentationsearch
D, H (P01552) extracellular regionsearch pathogenesissearch

Chain InterPro annotation
A, E MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B, F MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C, G
D, H Staphylococcal/Streptococcal toxin, beta-grasp domainsearch Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved sitesearch Staphylococcal/Streptococcal toxin, OB-foldsearch Staphylococcal/streptococcal toxin, bacterialsearch Enterotoxinsearch Superantigen, staphylococcal/streptococcal toxin, bacterialsearch Superantigen toxin, C-terminalsearch