1sdl Summary

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CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A

The structure was published by Schumacher, M.A., Dixon, M.M., Kluger, R., Jones, R.T., and Brennan, R.G., in 1995 in a paper entitled "Allosteric transition intermediates modelled by crosslinked haemoglobins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch cytosolsearch membranesearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch oxygen transportsearch bicarbonate transportsearch transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch
B, D (P68871) iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch blood microparticlesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch blood coagulationsearch nitric oxide transportsearch oxidation-reduction processsearch regulation of blood pressuresearch oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch transportsearch renal absorptionsearch platelet aggregationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch