1sdk Summary

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CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A

The structure was published by Schumacher, M.A., Dixon, M.M., Kluger, R., Jones, R.T., and Brennan, R.G., in 1995 in a paper entitled "Allosteric transition intermediates modelled by crosslinked haemoglobins." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch blood microparticlesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch cytosolsearch haptoglobin-hemoglobin complexsearch protein heterooligomerizationsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch small molecule metabolic processsearch transportsearch
B, D (P68871) oxygen bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch heme bindingsearch iron ion bindingsearch cytosolsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch hemoglobin complexsearch blood microparticlesearch hydrogen peroxide catabolic processsearch oxygen transportsearch renal absorptionsearch blood coagulationsearch small molecule metabolic processsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch platelet aggregationsearch nitric oxide transportsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch transportsearch bicarbonate transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch