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Hydroxynitrile Lyase from Hevea brasiliensis in complex with the natural substrate acetone cyanohydrin

Source organism: Hevea brasiliensis
Biochemical function: methyl jasmonate esterase activity
Biological process: salicylic acid metabolic process
Cellular component: not assigned

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EC 4.1.2.47: (S)-hydroxynitrile lyase

Reaction catalysed:
An aliphatic (S)-hydroxynitrile = cyanide + an aliphatic aldehyde or ketone
Systematic name:
(S)-cyanohydrin lyase (cyanide forming)
Alternative Name(s):
  • (S)-HbHNL
  • (S)-MeHNL
  • (S)-cyanohydrin carbonyl-lyase (cyanide forming)
  • (S)-cyanohydrin producing hydroxynitrile lyase
  • (S)-oxynitrilase
  • (S)-selective hydroxynitrile lyase
  • HbHNL
  • Hydroxynitrile lyase
  • MeHNL
  • Oxynitrilase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00561
Domain description: alpha/beta hydrolase fold
Occurring in:
  1. (S)-hydroxynitrile lyase
The deposited structure of PDB entry 1sc9 contains 1 copy of Pfam domain PF00561 (alpha/beta hydrolase fold) in (S)-hydroxynitrile lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. (S)-hydroxynitrile lyase
IPR045889
Domain description: Methylesterase/Alpha-hydroxynitrile lyase
Occurring in:
  1. (S)-hydroxynitrile lyase
IPR000073
Domain description: Alpha/beta hydrolase fold-1
Occurring in:
  1. (S)-hydroxynitrile lyase

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. (S)-hydroxynitrile lyase
The deposited structure of PDB entry 1sc9 contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in (S)-hydroxynitrile lyase. Showing 1 copy in chain A.
SCOP SCOP annotation
53585
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. (S)-hydroxynitrile lyase
The deposited structure of PDB entry 1sc9 contains 1 copy of SCOP domain 53585 (Hydroxynitrile lyase-like) in (S)-hydroxynitrile lyase. Showing 1 copy in chain A.

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