1s9q Summary


crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen

The structure was published by Greschik, H., Flaig, R., Renaud, J.P., and Moras, D., in 2004 in a paper entitled "Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Estrogen-related receptor gamma.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen-related receptor gamma P62509 (229-456) (ERR3_MOUSE)search Mus musculussearch < 90% 251 89%
B Estrogen-related receptor gamma P62509 (229-456) (ERR3_MOUSE)search Mus musculussearch < 90% 251 89%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62509 (229 - 456) Estrogen-related receptor gamma Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P62509) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch