1s9k Summary

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Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site

A publication describing this structure is not available. The depositing authors are Wang, D.search; Stroud, J.C.search; Chen, L.search

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This entry contains 5 copies of 5 unique biopolymers (complete list).

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C Nuclear factor of activated T-cells, cytoplasmic 2 Q13469 (399-678) (NFAC2_HUMAN)search Homo sapienssearch < 90% 280 100%
D Proto-oncogene protein c-fos P01100 (140-192) (FOS_HUMAN)search Homo sapienssearch < 90% 53 100%
E Transcription factor AP-1 P05412 (257-308) (JUN_HUMAN)search Homo sapienssearch < 90% 52 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13469 (399 - 678) Nuclear factor of activated T-cells, cytoplasmic 2 Homo sapiens
P01100 (140 - 192) Proto-oncogene protein c-fos Homo sapiens
P05412 (257 - 308) Transcription factor AP-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C NF-kappa-B/REL/DORSAL transcription factors, C-terminal domainsearch, Rel/Dorsal transcription factors, DNA-binding domainsearch Immunoglobulin-likesearch, Immunoglobulinssearch Rel homology domain (RHD)search, IPT/TIG domainsearch
D Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch
E Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
C (Q13469) regulation of transcription, DNA-templatedsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch
D (P01100) regulation of transcription, DNA-templatedsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch DNA bindingsearch nucleussearch
E (P05412) regulation of transcription, DNA-templatedsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch DNA bindingsearch nucleussearch

Chain InterPro annotation
C IPT domainsearch Nuclear factor of activated T cells (NFAT)search p53-like transcription factor, DNA-bindingsearch Rel homology domainsearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch
D AP-1 transcription factorsearch Basic-leucine zipper domainsearch c-Fos/v-Fossearch
E Transcription factor Junsearch Basic-leucine zipper domainsearch Transcription factor, Skn-1-like, DNA-binding domainsearch Transcription Factor c-Jun/v-Junsearch