spacer Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site
CATH: Protein Structure Classification
CATH code 2.60.40.340 search
Domains
1s9kC01
Name Human il-2 arre1 promoter element, plus strand. Chain: a. Engineered:yes. Human il-2 arre1 promoter element, minus strand. Chain: b. Engineered: yes. Nuclear factor of activated t-cells, cytoplasmic 2. Chain:c. Synonym: t cell transcription factor nfat1, nfat pre- existing subunit, nf-atp. Engineered: yes. Proto-oncogene protein c-fos. Chain: d.Synonym: cellular oncogene fos, g0/g1 switch regulatory protein 7. Engineered: yes. Transcription factor ap-1. Chain: e. Synonym: activatorprotein 1, ap1, proto-oncogene c-jun, v- jun avian sarcoma virus 17 oncogene homolog, p39. Engineered: yes
Source Yes. Other_details: solid phase synthesis. Yes. Other_details: solid phase synthesis. Homo sapiens. Human. Organism_taxid: 9606. Gene: nfatc2, nfat1, nfatp. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: fos, g0s7.Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers C
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulin-like search
 
CATH code 2.60.40.10 search
Domains
1s9kC02
Name Human il-2 arre1 promoter element, plus strand. Chain: a. Engineered:yes. Human il-2 arre1 promoter element, minus strand. Chain: b. Engineered: yes. Nuclear factor of activated t-cells, cytoplasmic 2. Chain:c. Synonym: t cell transcription factor nfat1, nfat pre- existing subunit, nf-atp. Engineered: yes. Proto-oncogene protein c-fos. Chain: d.Synonym: cellular oncogene fos, g0/g1 switch regulatory protein 7. Engineered: yes. Transcription factor ap-1. Chain: e. Synonym: activatorprotein 1, ap1, proto-oncogene c-jun, v- jun avian sarcoma virus 17 oncogene homolog, p39. Engineered: yes
Source Yes. Other_details: solid phase synthesis. Yes. Other_details: solid phase synthesis. Homo sapiens. Human. Organism_taxid: 9606. Gene: nfatc2, nfat1, nfatp. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: fos, g0s7.Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers C
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 1.20.5.170 search
Domains
1s9kD00
Name Human il-2 arre1 promoter element, plus strand. Chain: a. Engineered:yes. Human il-2 arre1 promoter element, minus strand. Chain: b. Engineered: yes. Nuclear factor of activated t-cells, cytoplasmic 2. Chain:c. Synonym: t cell transcription factor nfat1, nfat pre- existing subunit, nf-atp. Engineered: yes. Proto-oncogene protein c-fos. Chain: d.Synonym: cellular oncogene fos, g0/g1 switch regulatory protein 7. Engineered: yes. Transcription factor ap-1. Chain: e. Synonym: activatorprotein 1, ap1, proto-oncogene c-jun, v- jun avian sarcoma virus 17 oncogene homolog, p39. Engineered: yes
Source Yes. Other_details: solid phase synthesis. Yes. Other_details: solid phase synthesis. Homo sapiens. Human. Organism_taxid: 9606. Gene: nfatc2, nfat1, nfatp. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: fos, g0s7.Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers D
Hierarchy
Class Mainly Alphasearch
Architecture Up-down Bundle search
Topology Single alpha-helices involved in coiled-coils or other helix-helix interfaces search
Homologous superfamily Single alpha-helices involved in coiled-coils or other helix-helix interfaces search
 
CATH code 1.20.5.170 search
Domains
1s9kE00
Name Human il-2 arre1 promoter element, plus strand. Chain: a. Engineered:yes. Human il-2 arre1 promoter element, minus strand. Chain: b. Engineered: yes. Nuclear factor of activated t-cells, cytoplasmic 2. Chain:c. Synonym: t cell transcription factor nfat1, nfat pre- existing subunit, nf-atp. Engineered: yes. Proto-oncogene protein c-fos. Chain: d.Synonym: cellular oncogene fos, g0/g1 switch regulatory protein 7. Engineered: yes. Transcription factor ap-1. Chain: e. Synonym: activatorprotein 1, ap1, proto-oncogene c-jun, v- jun avian sarcoma virus 17 oncogene homolog, p39. Engineered: yes
Source Yes. Other_details: solid phase synthesis. Yes. Other_details: solid phase synthesis. Homo sapiens. Human. Organism_taxid: 9606. Gene: nfatc2, nfat1, nfatp. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: fos, g0s7.Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers E
Hierarchy
Class Mainly Alphasearch
Architecture Up-down Bundle search
Topology Single alpha-helices involved in coiled-coils or other helix-helix interfaces search
Homologous superfamily Single alpha-helices involved in coiled-coils or other helix-helix interfaces search
 
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