1s9i Summary

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X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP

The structure was published by Ohren, J.F., Chen, H., Pavlovsky, A., et al., Barrett, S., Tecle, H., and Hasemann, C.A., in 2004 in a paper entitled "Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Dual specificity mitogen-activated protein kinase kinase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dual specificity mitogen-activated protein kinase kinase 2 P36507 (55-400) (MP2K2_HUMAN)search Homo sapienssearch < 90% 354 85%
B Dual specificity mitogen-activated protein kinase kinase 2 P36507 (55-400) (MP2K2_HUMAN)search Homo sapienssearch < 90% 354 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P36507 (55 - 400) Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P36507) protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch