1s78 Summary

pdbe.org/1s78
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Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

The structure was published by Franklin, M.C., Carey, K.D., Vajdos, F.F., Leahy, D.J., De Vos, A.M., and Sliwkowski, M.X., in 2004 in a paper entitled "Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.25 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Receptor protein-tyrosine kinase erbB-2, Pertuzumab Fab light chain, and Pertuzumab Fab heavy chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Receptor protein-tyrosine kinase erbB-2 P04626 (23-646) (ERBB2_HUMAN)search Homo sapienssearch < 90% 624 91%
B Receptor protein-tyrosine kinase erbB-2 P04626 (23-646) (ERBB2_HUMAN)search Homo sapienssearch < 90% 624 91%
C Pertuzumab Fab light chain Q7Z3Y4 (23-236) (Q7Z3Y4_HUMAN)search Homo sapienssearch 90% 214 100%
E Pertuzumab Fab light chain Q7Z3Y4 (23-236) (Q7Z3Y4_HUMAN)search Homo sapienssearch 90% 214 100%
D Pertuzumab Fab heavy chain Not available
Mus musculussearch Not available 226 98%
F Pertuzumab Fab heavy chain Not available
Mus musculussearch Not available 226 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04626 (23 - 646) Receptor protein-tyrosine kinase erbB-2 Homo sapiens
Q7Z3Y4 (23 - 236) Pertuzumab Fab light chain Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B L domainsearch, Growth factor receptor domainsearch 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch
C, E V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch Immunoglobulin C1-set domainsearch, Immunoglobulin V-set domainsearch
D, F V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P04626) transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A, B Receptor L-domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch
C, E Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
D, F Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch