1s6c Summary

pdbe.org/1s6c
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Crystal structure of the complex between KChIP1 and Kv4.2 N1-30

The structure was published by Zhou, W., Qian, Y., Kunjilwar, K., Pfaffinger, P.J., and Choe, S., in 2004 in a paper entitled "Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Kv4 potassium channel-interacting protein KChIP1b and Potassium voltage-gated channel subfamily D member 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Kv4 potassium channel-interacting protein KChIP1b Q8R426 (45-227) (KCIP1_RAT)search Rattus norvegicussearch < 90% 183 91%
B Potassium voltage-gated channel subfamily D member 2 Q63881 (1-30) (KCND2_RAT)search Rattus norvegicussearch < 90% 30 70%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8R426 (45 - 227) Kv4 potassium channel-interacting protein KChIP1b Rattus norvegicus
Q63881 (1 - 30) Potassium voltage-gated channel subfamily D member 2 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Calmodulin-likesearch EF-handsearch EF-hand domain pairsearch
B Shal-type voltage-gated potassium channelssearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q8R426) calcium ion bindingsearch
B (Q63881) voltage-gated potassium channel activitysearch voltage-gated potassium channel complexsearch potassium ion transportsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch Recoverin familysearch
B Shal-type voltage-gated potassium channelssearch