1s32 Summary

pdbe.org/1s32
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Molecular Recognition of the Nucleosomal 'Supergroove'

The structure was published by Edayathumangalam, R.S., Weyermann, P., Gottesfeld, J.M., Dervan, P.B., and Luger, K., in 2004 in a paper entitled "Molecular Recognition of the Nucleosomal 'Supergroove'" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This entry contains 41 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodecamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A histone H3 P84233 (2-136) (H32_XENLA)search Xenopus laevissearch 99% 135 73%
E histone H3 P84233 (2-136) (H32_XENLA)search Xenopus laevissearch 99% 135 73%
B Histone H4 P62799 (2-103) (H4_XENLA)search Xenopus laevissearch 99% 102 86%
F Histone H4 P62799 (2-103) (H4_XENLA)search Xenopus laevissearch 99% 102 86%
C histone H2A P06897 (2-120) (H2A1_XENLA)search Xenopus laevissearch 92% 119 89%
G histone H2A P06897 (2-120) (H2A1_XENLA)search Xenopus laevissearch 92% 119 89%
D Histone H2B P02281 (5-126) (H2B11_XENLA)search Xenopus laevissearch 97% 122 82%
H Histone H2B P02281 (5-126) (H2B11_XENLA)search Xenopus laevissearch 97% 122 82%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P84233 (2 - 136) histone H3 Xenopus laevis
P62799 (2 - 103) Histone H4 Xenopus laevis
P06897 (2 - 120) histone H2A Xenopus laevis
P02281 (5 - 126) Histone H2B Xenopus laevis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, E (P84233) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
B, F (P62799) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
C, G (P06897) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
D, H (P02281) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, E (P84233) protein heterodimerization activitysearch DNA bindingsearch protein bindingsearch nucleosome assemblysearch chromosomesearch nucleussearch nucleosomesearch nucleoplasmsearch
B, F (P62799) protein heterodimerization activitysearch DNA bindingsearch protein bindingsearch nucleosome assemblysearch nucleussearch chromosomesearch nucleosomesearch
C, G (P06897) protein heterodimerization activitysearch DNA bindingsearch nucleosome assemblysearch nucleosomesearch chromosomesearch nucleussearch
D, H (P02281) DNA bindingsearch protein heterodimerization activitysearch nucleosome assemblysearch nucleussearch nucleosomesearch chromosomesearch

Chain InterPro annotation
A, E Histone H3/CENP-Asearch Histone coresearch Histone-foldsearch
B, F Histone H4search Histone coresearch Histone-foldsearch Histone H4, conserved sitesearch
C, G Histone H2Asearch Histone coresearch Histone-foldsearch
D, H Histone H2Bsearch Histone coresearch Histone-foldsearch