1s20 Summary

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A novel NAD binding protein revealed by the crystal structure of E. Coli 2,3-diketogulonate reductase (YiaK) NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER82

The structure was published by Forouhar, F., Lee, I., Benach, J., et al., Acton, T.B., Montelione, G.T., and Tong, L., in 2004 in a paper entitled "A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Hypothetical oxidoreductase yiaK.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%
B Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%
C Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%
D Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%
E Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%
F Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%
G Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%
H Hypothetical oxidoreductase yiaK P37672 (1-332) (DLGD_ECOLI)search Escherichia coli K-12search 100% 340 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37672 (1 - 332) Hypothetical oxidoreductase yiaK Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H (P37672) L-sulfolactate dehydrogenase-likesearch Hypothetical Oxidoreductase Yiak; Chain: A, domain 1search, Hypothetical oxidoreductase yiak; domain 2search, Hypothetical oxidoreductase yiak; domain 3search PF02615: Malate/L-lactate dehydrogenasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D, E, F, G, H (P37672) 3-dehydro-L-gulonate 2-dehydrogenase activitysearch oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorsearch NAD+ bindingsearch oxidoreductase activitysearch oxidation-reduction processsearch metabolic processsearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Malate/L-lactate dehydrogenasesearch 2,3-diketo-L-gulonate reductasesearch