› 1s1n

Solution NMR

SH3 domain of human nephrocystin

Released:
DOI: 10.2210/pdb1s1n/pdb
PDB entry 1s1n coloured by chain, ensemble of 17 models, front view.
PDB entry 1s1n coloured by chain, ensemble of 17 models, side view.
PDB entry 1s1n coloured by chain, ensemble of 17 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis.
le Maire A, Weber T, Saunier S, Broutin I, Antignac C, Ducruix A, Dardel F
Proteins 59 347-55 (2005)
PMID: 15723349

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127394 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nephrocystin-1 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15259 (Residues: 147-212; Coverage: 9%)
Gene names: NPH1, NPHP1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry follwed by restrained simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6.
Delous et al. (2009)
2 more

4 mentions without citation

Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.
Wodarczyk et al. (2010)
3 more