1s0x Summary


Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2A

The structure was published by Kallen, J., Schlaeppi, J.M., Bitsch, F., Delhon, I., and Fournier, B., in 2004 in a paper entitled "Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Nuclear receptor ROR-alpha. This molecule has the UniProt identifier P35398 (RORA_HUMAN)search. The sample contained 270 residues which is < 90% of the natural sequence. Out of 270 residues 251 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Nuclear receptor ROR-alpha P35398 (271-523) (RORA_HUMAN)search Homo sapienssearch < 90% 270 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35398 (271 - 523) Nuclear receptor ROR-alpha Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35398) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear receptor RORsearch Nuclear hormone receptor, ligand-bindingsearch