1rze Summary

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X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES

The structure was published by Hakansson, K., Wehnert, A., and Liljas, A., in 1994 in a paper entitled "X-ray analysis of metal-substituted human carbonic anhydrase II derivatives." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1993.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch one-carbon metabolic processsearch response to zinc ionsearch bicarbonate transportsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch kidney developmentsearch response to organic substancesearch positive regulation of bone resorptionsearch regulation of chloride transportsearch odontogenesis of dentin-containing toothsearch response to steroid hormonesearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch response to estrogensearch regulation of anion transportsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch response to pHsearch cytoplasmsearch extracellular vesicular exosomesearch apical part of cellsearch basolateral plasma membranesearch plasma membranesearch cytosolsearch membranesearch microvillussearch axonsearch extracellular spacesearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch