1rze Summary



The structure was published by Hakansson, K., Wehnert, A., and Liljas, A., in 1994 in a paper entitled "X-ray analysis of metal-substituted human carbonic anhydrase II derivatives." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1993.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) myelin sheathsearch microvillussearch plasma membranesearch cytoplasmsearch extracellular vesicular exosomesearch extracellular spacesearch cytosolsearch membranesearch basolateral plasma membranesearch axonsearch apical part of cellsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch secretionsearch response to organic substancesearch response to steroid hormonesearch regulation of chloride transportsearch response to estrogensearch morphogenesis of an epitheliumsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch cellular response to fluid shear stresssearch odontogenesis of dentin-containing toothsearch regulation of intracellular pHsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch regulation of anion transportsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch one-carbon metabolic processsearch carbonate dehydratase activitysearch lyase activitysearch protein bindingsearch metal ion bindingsearch zinc ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch