1rza Summary



The structure was published by Hakansson, K., Wehnert, A., and Liljas, A., in 1994 in a paper entitled "X-ray analysis of metal-substituted human carbonic anhydrase II derivatives." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1993.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch cytosolsearch plasma membranesearch apical part of cellsearch myelin sheathsearch axonsearch membranesearch extracellular vesicular exosomesearch basolateral plasma membranesearch extracellular spacesearch microvillussearch response to steroid hormonesearch secretionsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch kidney developmentsearch response to pHsearch response to zinc ionsearch positive regulation of osteoclast differentiationsearch bicarbonate transportsearch response to estrogensearch small molecule metabolic processsearch one-carbon metabolic processsearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch cellular response to fluid shear stresssearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch response to organic substancesearch zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch