1rvw Summary

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R STATE HUMAN HEMOGLOBIN [ALPHA V96W], CARBONMONOXY

The structure was published by Puius, Y.A., Zou, M., Ho, N.T., Ho, C., and Almo, S.C., in 1998 in a paper entitled "Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch oxidation-reduction processsearch transportsearch response to hydrogen peroxidesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch endocytic vesicle lumensearch
B (P68871) oxygen bindingsearch heme bindingsearch iron ion bindingsearch peroxidase activitysearch protein bindingsearch hemoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch small molecule metabolic processsearch bicarbonate transportsearch nitric oxide transportsearch positive regulation of cell deathsearch oxygen transportsearch oxidation-reduction processsearch transportsearch platelet aggregationsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch blood coagulationsearch hydrogen peroxide catabolic processsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch