1rvw Summary



The structure was published by Puius, Y.A., Zou, M., Ho, N.T., Ho, C., and Almo, S.C., in 1998 in a paper entitled "Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) iron ion bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen bindingsearch heme bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch transportsearch protein heterooligomerizationsearch bicarbonate transportsearch oxygen transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch oxidation-reduction processsearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch membranesearch endocytic vesicle lumensearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch
B (P68871) haptoglobin bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch peroxidase activitysearch hemoglobin bindingsearch oxygen transportsearch transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch blood coagulationsearch bicarbonate transportsearch nitric oxide transportsearch small molecule metabolic processsearch receptor-mediated endocytosissearch platelet aggregationsearch regulation of blood pressuresearch protein heterooligomerizationsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolsearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch