1rsz Summary

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Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate

A publication describing this structure is not available. The depositing authors are Shi, W.search; Lewandowicz, A.search; Tyler, P.C.search; Furneaux, R.H.search; Almo, S.C.search; Schramm, V.L.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Purine nucleoside phosphorylase. This molecule has the UniProt identifier P00491 (PNPH_HUMAN)search. The sample contained 289 residues which is 100% of the natural sequence. Out of 289 residues 282 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Purine nucleoside phosphorylase P00491 (1-289) (PNPH_HUMAN)search Homo sapienssearch 100% 289 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00491 (1 - 289) Purine nucleoside phosphorylase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00491) Purine and uridine phosphorylasessearch Rossmann foldsearch PF01048: Phosphorylase superfamilysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00491) purine-nucleoside phosphorylase activitysearch catalytic activitysearch transferase activity, transferring pentosyl groupssearch transferase activity, transferring glycosyl groupssearch drug bindingsearch nucleoside bindingsearch phosphate ion bindingsearch purine nucleobase bindingsearch transferase activitysearch nucleobase-containing compound metabolic processsearch nucleoside metabolic processsearch purine nucleotide catabolic processsearch nucleobase-containing small molecule metabolic processsearch response to drugsearch small molecule metabolic processsearch nicotinamide riboside catabolic processsearch urate biosynthetic processsearch purine-containing compound salvagesearch purine nucleobase metabolic processsearch NAD biosynthesis via nicotinamide riboside salvage pathwaysearch positive regulation of alpha-beta T cell differentiationsearch interleukin-2 secretionsearch immune responsesearch positive regulation of T cell proliferationsearch inosine catabolic processsearch cytoplasmsearch cytoskeletonsearch cytosolsearch intracellularsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Nucleoside phosphorylase domainsearch PNP/MTAP phosphorylasesearch Purine nucleoside phosphorylasesearch Purine nucleoside phosphorylase I, inosine/guanosine-specificsearch Purine phosphorylase, family 2, conserved sitesearch