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PDBe Entry: 1rr8 
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
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ISOMERASE/DNA
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X-RAY DIFFRACTION
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Resolution: 2.6 Å, R-factor: 24.2%, Free R-factor: 29.4%, Spacegroup: P 1 21 1
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06/07/2004, deposition: 08/12/2003, last revision: 24/02/2009
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Chrencik, J.E.; Staker, B.L.; Burgin, A.B.; Stewart, L.; Redinbo, M.R.
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Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.MOL.BIOL. vol:339, pag:773-784 (2004) [PubMed ID 15165849 ]
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Protein-DNA complex, Topotecan, Camptothecin, Nucleic Acid, Human Topoisomerase I, ISOMERASE/DNA COMPLEX
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5.99.1.2 ExPASy BRENDA (C)
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Homo sapiens(human) 9606(C)
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DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) P11387 (C)
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A, B, C
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| A |
5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' |
DNA |
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22 |
100% |
| B |
5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3' |
DNA |
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22 |
100% |
| C |
DNA topoisomerase I |
Protein |
P11387 (TOP1_HUMAN)
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565 |
87% |
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| A |
2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID |
TTG
TTC
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